In the briefing of M17: Infestation, Miles asks the Federation Force to collect Metroid Eggs for study. Miles's motivations for this request are suspicious, and may be foreshadowing the Galactic Federation's experimentation with Metroids in Metroid: Other M and Metroid Fusion. If an Egg is acquired, a secret ending will be unlocked that shows Sylux hatching the Egg in a Federation facility.
- In the first footage of the game shown at E3 2015, General Miles' speech was represented with a 2-D icon. This was later changed to a 3-D mobile camera feed in the final game.
- Miles appears in the Metroid Prime: Blast Ball demo upon loading the game for the first time. Miles introduces him/herself, and asks the player whether they wish to Practice first or play a game of Blast Ball head on.
- Miles, in commanding the playable protagonist, serves a similar role as Commander Adam Malkovich in Other M and Fusion.