The giants are a predator on Degrade in Samus & Joey: Volume 2. They resemble large humanoid beasts with spikes and five-fingered hands. Several of them attempt to kill the survivors of the Special Forces Ship Otowa crash, although Samus Aran intervenes and destroys most of them. One takes Diana Apronika hostage only to be killed seconds later by her son, Joey.
Despite their fearsome nature, they are prey to the Amok penguins, and are seen to retreat when they appear. One giant failed to escape and became a casualty of the onslaught.