They are seen in the Biosphere. The Griptian's head is similar to an aardvark's and it has an armored back, a tail and giant claws. It is capable of attacking by ramming into Samus while rolling around, as well as slashing and tackling her to the ground. It resembles an Arachnus in appearance and attack.
When the Griptian is rolling, it can easily be dislodged with a Bomb or a Charge Beam shot, however, the Griptian's armor will deflect the attack, nullifying damage. Samus can easily defeat it by shooting it with a Missile or perform an Overblast to knock it down and finish it off with a Lethal Strike, or simply dodge its pounce which primes for a Lethal Strike as well.
- Concept art states that the Griptian was transformed into a monster as an experimental test subject.
- When Overblast is attempted but Samus fails to fire on time, the Griptian will throw her off but no damage is incurred.
- A single Griptian can be found ensnared in Kihunter webbing in the room directly outside the Biological Experiment Floor.