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Main Ventilation Shaft Section D is part of a network of ventilation shafts in the Frigate Orpheon in Metroid Prime that Samus travels through after the battle with the Parasite Queen in order to escape the frigate.
- Main Ventilation Shaft Section D, along with Main Ventilation Shaft Sections E and F, did not survive the crash on Tallon IV, unlike the other half of the Main Ventilation Shaft.