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Main Ventilation Shaft Section F is part of a network of ventilation shafts in the Frigate Orpheon in Metroid Prime that Samus travels through after the Parasite Queen battle in order to escape the frigate.
- Main Ventilation Shaft Section F, along with Main Ventilation Shaft Sections D and E, did not survive the crash into Tallon IV, unlike the other half of the Main Ventilation Shaft.