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The Metroid Prime Theme is, as the name implies, the main theme of Metroid Prime. It is also featured in the Opening/Menu (Metroid Prime) song in Super Smash Bros. Brawl, though a narration by Jay Ward was added in the part where the opening theme is heard.
The theme is present in Metroid Prime 2: Echoes Bonus Disc, where it is used in the chronicle while playing a movie with clips of Prime. Metroid Prime Trilogy also features the theme as one song that can be purchased in the Soundtrack Gallery.
Part of the theme plays on the menu screen of Metroid Fusion.
Part of theme plays on the Other M menu screen. The same part of the theme also plays at several other points in the game: during the introduction when Samus detects the Bottle Ship's distress signal, and later when she first encounters the 07th Platoon.
The theme can be heard here: .